ea0016oc1.6 | Neuroendocrinology and pituitary | ECE2008
Kola Blerina
, Christ-Crain Mirjam
, Farkas Imre
, Wittmann Gabor
, Lolli Francesca
, Seboek Dalma
, Harvey-White Judith
, Kunos George
, Muller Beat
, Arnaldi Giorgio
, Giacchetti Gilberta
, Boscaro Marco
, Grossman Ashley B
, Fekete Csaba
, Korbonits Marta
Ghrelin, cannabinoids and glucocorticoids have all orexigenic and widespread metabolic effects. AMPK is a major controller of many metabolic processes. We have studied the effects of ghrelin and glucocorticoids and their interaction with endocannabinoids using cannabinoid-receptor-1 (CB1) knock-out mice and CB1 antagonist-treated mice, and using tissue samples from patients with Cushings syndrome and from a rodent model of Cushings syndrome. AMPK activity and downs...